57. Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation
Faustino H; Silva MJSA; Veiros LF; Bernardes GJL; Gois PMP
Chem. Sci. 2016, 7, 5052-5058

56. Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents
Rodrigues T; Sieglitz F; Bernardes GJL*
Chem. Soc. Rev. 2016, 45, 6130–6137

Emerging Investigators Issue 2016.
See contributors’ profile in : Chem. Soc. Rev. 2016, 45, 6089–6092

55. Construction of Homogeneous Antibody-drug Conjugates using Site-selective Protein Chemistry
Akkapeddi P; Azizi S-A; Freedy A; Cal PMSD; Gois PMP; Bernardes GJL*
Chem. Sci. 2016, 7, 2954-2963

54. Urban endocrine disruptors targeting breast cancer proteins
Montes-Grajales D; Bernardes GJL*; Olivero-Verbel JT
Chem. Res. Toxicol. 2016, 29, 150–161

53. Site-selective protein-modification chemistry for basic biology and drug development
Krall N; da Cruz FP; Boutureira O; Bernardes GJL*
Nature Chem. 2016, 8, 103–113

Highlighted in Nature Chem 2016, 8, 91 - A little less conjugation, a little more accuracy.

52. Sulfur-Limonene Polysulfide: A Material Synthesized Entirely from Industrial Waste and Its Use in Removing Toxic Metals from Water and Soil
Crockett MP; Evans AM; Worthington MJH; Albuquerque IS; Slattery AD; Gibson CT; Bernardes GJL, Chalker JM
Angew. Chem. Int. Ed., 2016, 55, 1714–1718

Selected as a Hot Paper.
Highlighted in Chemical&Engineering News, November 2, 2015.

51. A N-acetyl cysteine ruthenium tricarbonyl conjugate enables simultaneous release of CO and ablation of ROS species
Seixas JD; Chaves-Ferreira M; Montes-Grajales D; Gonçalves AM; Marques AR; Saraiva LM; Olivero-Verbel J; Romão CC; Bernardes GJL*
Chem. Eur. J. 2015, 21, 14708–14712

 Hot Paper.

50. An artificial CO-releasing metalloprotein built by histidine-selective metallation
Albuquerque IS; Jeremias HF; Chaves-Ferreira M; Matak-Vinkovic D; Boutureira O; Romão CC; Bernardes GJL*
Chem. Commun. 2015, 51, 3993–3996

49. Advances in chemical protein modification
Boutureira O; Bernardes GJL*
Chem. Rev. 2015, 115, 2174–2195

48. Spontaneous CO Release from Ru^II(CO)₂-Protein Complexes in Aqueous Solution, Cells and Mice
Ferreira MC; Albuquerque IS; Matak-Vinkovic D; Coelho AC; Carvalho SM; Saraiva LM; Romão CC; Bernardes GJL*
Angew. Chem. Int. Ed. 2015, 54, 1172–1175

47. Collagen labelling with an azide-proline chemical reporter in live cells
Amgarten B; Rajan R; Martínez-Sáez N; Oliveira BL; Albuquerque IS; Reid DG; Brooks RA; Duer MJ; Bernardes GJL*
Chem. Commun. 2015, 51, 5250–5252

Emerging Investigators Issue 2015.

46. Synthesis of Fluorosugar Reagents for the Construction of Well-Defined Fluoroglycoproteins
Salvadó M; Amgarten B; Castillón S; Bernardes GJL*; Boutureira O
Org. Lett. 2015, 17, 2836–2839

45. Deciphering the Non‐Equivalence of Serine and Threonine O‐Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti‐MUC1 Antibody
Martínez-Sáez N; Castro-López J; Valero-González J, Madariaga D; Compañón I; Somovilla VJ; Salvadó M; Asensio JL; Jiménez-Barbero J; Avenoza A; Busto JH; Bernardes GJL; Peregrina JM; Hurtado-Guerrero R; Corzana F
Angew. Chem. Int. Ed. 2015, 54, 9830–9834

44. Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation
Lira-Navarrete E; de las Rivas M; Compañón I; Pallarés MC; Kong Y; Iglesias-Fernández J; Bernardes GJL; Peregrina JM; Rovira C; Bernadó P; Bruscolini P; Clausen H; Lostao A; Corzana F; Hurtado-Guerrero R
Nature Commun. 2015, 6, 6937

43. Peptide anchor for folate-targeted liposomal delivery
Nogueira E; Mangialavori IC; Loureiro A; Azoia NG; Sárria MP; Nogueira P; Freitas J; Härmark J; Shimanovich U; Rollett A; Lacroix G; Bernardes GJL, Guebitz GM; Herbert H; Moreira A; Carmo AM; Rossi JPFC; Gomes AC; Preto A; Cavaco-Paulo A
Biomacromolecules 2015, 16, 2904–2910

42. Size Controlled Protein Nanoemulsions for Active Targeting of Folate Receptor Positive Cells
Loureiro A; Nogueira E; Azoia NG; Sárria MP; Abreu AS; Shimanovich U; Rollet A; Härmark J; Hebert H; Guebitz G; Bernardes GJL; Preto A; Gomes AC; Cavaco-Paulo A
Colloids Surf. B Biointerfaces 2015, 135, 90–98

41. Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice
Nogueira E; Lager F; Le Roux D; Nogueira P; Freitas J; Charvet C; Renault G; Loureiro A; Almeida CR; Ohradanova-Repic A; Machacek C; Bernardes GJL; Moreira A; Stockinger H; Burnet M; Carmo AM; Gomes AC; Preto A; Bismuth G; Cavaco-Paulo A
Biomed. Nanotechnol. 2015, 11, 2243–2252

40. Folic Acid-Tagged Protein Nanoemulsions Loaded with CORM-2 Enhance the Survival of Mice Bearing Subcutaneous A20 Lymphoma Tumors
Loureiro A; Bernardes GJL*; Shimanovich U; Sárria MP; Nogueira E; Preto A; Gomes AC; Cavaco-Paulo A
Nanomedicine 2015, 11, 1077–1083

39. A contribution to the rational design of Ru(CO)₃Cl₂L complexes for in vivo delivery of CO
Seixas JD; Santos MFA; Mukhopadhyay A; Coelho AC; Reis PM; Veiros LF; Marques AR; Penacho N; Gonçalves AML; Romão MJ; Bernardes GJL; Santos-Silva, T; Romão CC
Dalton Trans. 2015, 44, 5058–5075

38. Functionalized protein nanoemulsions by incorporation of chemically modified BSA
Loureiro A; Abreu AS; Sárria MP; Figueiredo MCO; Saraiva LM; Bernardes GJL; Gomes AC; Cavaco-Paulo A
RSC Advances 2015, 5, 4976–4983

37. Highlights from the 49^th EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2014
Bernardes GJL*; Lawrence AL
Chem. Commun. 2014, 50, 10752–10757

36. Cysteine Selective Reactions for Antibody Conjugation
Cal PMSD; Bernardes GJL*; Gois PMP
Angew. Chem. Int. Ed. 2014, 53, 10585–10587

35. Carbon-monoxide releasing molecules for the delivery of therapeutic CO in vivo
García-Gallego S; Bernardes GJL*
Angew. Chem. Int. Ed. 2014, 53, 9712–9721

34. Protein Micro and Nano Capsules for Biomedical Applications
Shimanovich U; Bernardes GJL*, Knowles TJ; Cavaco-Paulo A
Chem. Soc. Rev. 2014, 43, 1361–1371

33. Highlights from the 48^th EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2013
Bernardes GJL*
Chem. Commun. 2013, 49, 8578–8582

32. Synthetically defined glycoprotein vaccines: Current status & future directions
Adamo D; Nilo A; Castagner B; Boutureira O; Berti F; Bernardes GJL*
Chem. Sci. 2013, 4, 2995–3008

EMBO Fellow with Prof. Dario Neri

31. A Small Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors
Krall N; Pretto, F; Decurtins W; Bernardes GJL; Supuran CT; Neri D
Angew. Chem. Int. Ed. 2014, 53, 4231–4235

30. Curative Properties of Non-Internalizing Antibody-Drug Conjugates Based on Maytansinoids
Perrino E; Steiner M; Krall N; Bernardes GJL; Pretto F; Casi G; Neri D
Cancer Res. 2014, 74, 2569–2578

29. Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature
Steiner M; Hartmann I; Perrino E; Casi G; Brighton S; Jelesarov I; Bernardes GJL*; Neri D
Chem. Sci. 2013, 4, 297–302

28. Site-specific Chemical Modification of Antibody Fragments with Traceless Cleavable Linkers
Bernardes GJL; Steiner M; Hartmann I; Neri D; Casi G
Nature Protoc. 2013, 8, 2079–2089

27. Fucose-specific Conjugation of Hydrazide Derivatives to a Vascular-targeting Monoclonal Antibody in IgG Format”
Zuberbühler K; Casi G; Bernardes GJL; Neri D
Chem. Commun. 2012, 48, 7100–7102

26. A Traceless Vascular Targeting Antibody-Drug Conjugate for Cancer Therapy
Bernardes GJL; Casi G; Trüssel S; Hartmann I; Schwager K; Scheuermann J; Neri D
Angew. Chem. Int. Ed. 2012, 51, 941–944

Very Important Paper (VIP).
Highlighted in Chimia 2012, 66, 130; ETH Life – “Starving Cancer”.

Group Leader at the biotechnology company Alfama Lta.

25. Generation of liver specific carbon monoxide-releasing molecule (CO-RM) as drug candidates for the treatment of acute liver injury: targeting of CO-RMs to the liver
Marques AR; Kromer L; Gallo DJ; Penacho NM; Rodrigues SS; Seixas JD; Bernardes GJL; Reis PM; Otterbein SL; Ruggieri RA; Gonçalves ASG; Gonçalves AML; De Matos MN; Bento I; Otterbein LE; Blättler WA; Romão CC
Organometallics 2012, 31, 5810-5822

Special issue Organometallics in Biology and Medicine.

24. Developing Drug Molecules for Therapy with Carbon Monoxide
Romão CC; Seixas JD; Blättler WA; Bernardes GJL*
Chem. Soc. Rev. 2012, 41, 3571–3583

23. A Novel CO-releasing Molecule Fully Protects Mice from Severe Malaria
Pena AC; Penacho N; Mancio da Silva L; Neres R; Seixas JD; Fernandes AC; Romão CC; Mota MM; Bernardes GJL*; Pamplona A
Antimicrob. Agents Chemother. 2012, 56, 1281–1290

22. Towards Improved Therapeutic CORMs: Understanting the Reactivity of CORM-3 with Proteins
Santos-Silva T; Mukhopadkyay A; Seixas JD; Bernardes GJL; Romão CR; Romão MJ
Curr. Med. Chem. 2011, 18, 3361–3366

21. CORM-3 Reactivity Towards Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysosyme Complex
Santos-Silva T; Mukhopadkyay A; Seixas JD; Bernardes GJL*; Romão CR; Romão MJ
J. Am. Chem. Soc. 2011, 133, 1192–1195

Marie-Curie Fellow with Prof. Peter Seeberger

20. Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting
Bernardes GJL; Kikkeri R; Maglinao M; Laurino P; Collot M; Hong SY; Lepenies B; Seeberger PH
Org. Biomol. Chem. 2010, 8, 4987-4996

Hot Article.

19. Combined Approaches to the Synthesis and Study of Glycoproteins
Bernardes GJL; Castagner B; Seeberger PH
ACS Chem. Biol. 2009, 4, 703–713

Most accessed articles from ACS Chemical Biology in 2009.

D.Phil. with Prof. Ben Davis

18. Precise Probing of Residue Roles by Post-translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites
Dadová J; Wu K-J; Isenegger PG; Errey JC; Bernardes GJL, Chalker JM; Raich K; Rovira C; Davis BG
ACS Cent. Sci. 2017, 3, 1168–1173

17. Post-translational mutagenesis: a chemical strategy for exploration of protein side-chain diversity
Wright TH; Bower BJ; Chalker JM; Bernardes GJL; Wiewiora R; Ng WL; Raj R; Faulkner S; Vallée MRJ; Phanumartwiwath A; Coleman OD; Thézénas ML; Khan M; Galan SRG; Lercher L; Schombs MW; Gerstberger S; Palm-Espling ME; Baldwin MJ; Kessler BM; Claridge TDW; Mohammed S; Davis BG
Science 2016, 354, 597

Highlight in Science 2016, 354, 553–554; Chemical&Engineering News, September 26, 2016; Nature Methods 2016, 13, 907.

16. Rationally Designed Short Polyisoprenol-linked PglB Substrates for Engineered Polypeptide N-Glycosylation
Liu F; Vijayakrishnan B; Faridmoayer A; Taylor TA; Parsons TB; Bernardes GJL; Kowarik M; Davis BG
J. Am. Chem. Soc. 2014, 15, 566–569

15. SeS-linked Homogeneous Glycopeptides and Glycoproteins: Synthesis of Human Hepatic ‘Se-Metabolite A’
Boutureira O; Bernardes GJL; Fernández-González M; Davis BG
Angew. Chem. Int. Ed. 2012, 51, 1432–1436

14. Direct Radiolabelling of Proteins at Cysteine using [18F]-fluorosugars
Boutureira O; Bernardes GJL; D’Hooge F; Davis BG
Chem. Commun. 2011, 30, 10010–10012

13. Methods for the Conversion of Cysteine to Dehydroalanine on Peptides and Proteins
Chalker JM; Gunnoo SB; Boutureira O; Gerstberger SC; Fernández-González M; Bernardes GJL; Griffin L; Hailu H; Schofield CJ; Davis BG
Chem. Sci. 2011, 2, 1666–1676

Featured on the Cover.

12. A “Tag-and-Modify” Approach to Site-selective Protein Modification
Chalker JM; Bernardes GJL; Davis BG
Acc. Chem. Res. 2011, 44, 730–741

Special issue on Bioorthogonal Chemistry in Biology.

11. Site-selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations
Bernardes GJL; Linderoth L; Doores KJ; Boutureira O; Davis BG
ChemBioChem 2011, 12, 1383–1386

Most accessed articles from ChemBioChem in 2011.

10. A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates
Grayson EJ; Bernardes GJL; Chalker JM; Boutureira O; Koeppe JR; Davis BG
Angew. Chem. Int. Ed. 2011, 50, 4127–4132

9. Site-selective chemoenzymatic construction of synthetic glycoproteins using endoglycosidases
Fernández-González M; Boutureira O; Bernardes GJL; Chalker JM; Young MA; Errey JC; Davis BG
Chem. Sci. 2010, 1, 709–715

8. Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins
Boutureira O; D’Hooge F; Fernández-González M; Bernardes GJL; Sánchez-Navarro M; Koeppe JR; Davis BG
Chem. Commun. 2010, 46, 8142–8144

Hot Article and featured on the Cover.

7. Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology
Chalker JM; Bernardes GJL; Lin AY; Davis BG
Chem. Asian J., 2009, 4, 630–640

Most accessed articles from Chem. Asian J. in 2009 and 2010.

6. Allyl Sulfides are Priviliged Substrates in aqueous Olefin Cross-Metathesis: Application to Site-selective Protein Modification
Lin AY; Chalker JM; Floyd N; Bernardes GJL; Davis BG
J. Am. Chem. Soc. 2008, 130, 9642–9643

Highlighted in Chemical&Engineering News, July 14, 2008; Nature Chem. Biol. 2008, 4, 527; Chemistry World, 2008, 5, 20; Faculty of 1000 Biology.

5. Chemical Site-Selective Prenylation of Proteins
Gamblin DP; van Kasteren SI; Bernardes GJL; Chalker JM; Oldham NJ; Fairbanks AJ; Davis BG
Mol. BioSyst. 2008, 4, 558–561

4. Facile Conversion of Cysteine and AlkylCysteines to Dehydroalanine: Versatile and Switchable Access to Functionalized Proteins
Bernardes GJL; Chalker, JM; Errey JC; Davis BG
J. Am. Chem. Soc. 2008, 130, 5052–5053

Highlighted in Nature Chem. Biol. 2008, 4, 527–528; Chemical&Engineering News, March 31, 2008; Chemistry World, 2008, 5, 20; Chem. Commun. 2008, 6441.

3. From Disulfide- to Thioether-linked Glycocoproteins
Bernardes GJL; Grayson EJ; Thompson S; Chalker JM; Errey JC; Oualid FE; Claridge TDW; Davis BG
Angew. Chem. Int. Ed. 2008, 47, 2244–2247

Highlighted in Angew. Chem. Int. Ed. 2008, 47, 5496-5499.

2. A Trisulfide-linked Glycoprotein
Bernardes GJL; Marston JP; Batsanov AS; Howard JAK; Davis BG
Chem. Commun. 2007, 3145–3147

1. The Direct Formation of Glycosyl Thiols from Reducing Sugars Allows One-pot Protein Glycoconjugation
Bernardes GJL; Gamblin DP; Davis BG
Angew. Chem. Int. Ed. 2006, 45, 4007–4011