ALL PUBLICATIONS
For citation analysis and h-index, check my Google Scholar.
179. Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions
TForno GM; Latocheski E; Machado AB; Becher J; Dunsmor L; St. John AL; Oliveira BL; Navo CD; Jiménez-Osés G; Fior R; Domingos JB*; Bernardes GJL*
J. Am. Chem. Soc. 2023, 145, 19, 10790–10799
178. Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules
Mikutis S*; Rebelo M; Yankova E; Gu M; Tang C; Coelho AR; Yang M; Hazemi ME; Miranda MP; Eleftheriou M; Robertson M; Vassiliou GS; Adams DJ; Simas JP; Corzana F; Schneekloth Jr. JS; Tzelepis K*; Bernardes GJL*
ACS Cent. Sci. 2023, 9, 5, 892–904
177. Clinical and pre-clinical utility of click chemistry
Mikutis S; Bernardes GJL*
Cell 2023, 186, 3, 662 - 662.E1
176. Strategies for Conditional Regulation of Proteins
Nadendla K, Simpson CG, Becher J, Journeaux T, Cabeza-Cabrerizo M, Bernardes GJL*
JACS Au 2023, 3, 2, 344–357
175. A Selective SARS-CoV‑2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species
Tang C; Coelho AR; Rebelo M; Kiely-Collins H; Carvalho T; Bernardes GJL*
ACS Cent. Sci. 2023, 9, 1, 109–121
174. Fragment-based computational design of antibodies targeting structured epitopes
Rangel MA; Bedwell A; Costanzi E; Taylor RJ; Russo R; Bernardes GJL; Ricagno S; Frydman J; Vendruscolo M*; Sormanni P*
Sci. Adv. 2022, 8, eabp9540
173. Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors
Sousa BB; Almeida CR; Barahona AF; Lopes R; Martins-Logrado A; Cavaco M; Neves V; Carvalho LAR; Labão-Almeida C; Coelho AR; Bento ML; Lopes RMRM; Oliveira BL; Castanho MARB; Neumeister P; Deutsch A; Vladimer GI; Krall N; João C; Corzana F; Seixas JD; Fior R, Bernardes GJL*
ACS Pharmacol. Transl. Sci. 2022, 5, 11, 1156–1168
172. Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones
Afonso CF; Marques MC; António JPM; Cordeiro C; Gois PMP; Cal PMSD; Bernardes GJL*
Angew. Chem. Int. Ed. 2022, 61, e202208543
Selected as a Hot Paper.
171. π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation
Taylor RJ; Rangel MA; Geeson MB; Sormanni P; Vendruscolo M; Bernardes GJL*
J. Am. Chem. Soc. 2022, 144, 14404–14419
170. The impact of activity-based protein profiling in malaria drug discovery
Carvalho LAR*; Bernardes GJL*
ChemMedChem 2022, 17, e202200174
169. Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination
Dunsmore L; Navo CD; Becher J; Gil de Montes E; Guerreiro A; Hoyt E; Brown L; Zelenay V; Mikutis S; Cooper J; Barbieri I; Lawrinowitz S; Siouve E; Martin E; Ruivo PR; Rodrigues T; da Cruz FP; Werz O; Vassiliou G; Ravn P; Jiménez-Osés G*; Bernardes GJL*
Nat. Chem. 2022, 14, 754–765
168. Platform for orthogonal N-cysteine-specific protein modification enabled by cyclopropenone reagents
Istrate A; Geeson MB; Navo CD; Sousa BB; Marques MC; Taylor RJ; Journeaux T; Oehler SR; Mortensen MR; Deery MJ; Bond AD; Corzana F; Jiménez-Osés G*; Bernardes GJL*
J. Am. Chem. Soc. 2022, 144, 10396–10406
167. Chemical and enzymatic methods for post-translational protein–protein conjugation
Taylor RJ; Geeson MB; Journeaux T; Bernardes GJL*
J. Am. Chem. Soc. 2022, 144, 14404–14419
166. Structural insights into TRPV2 activation by small molecules
Pumroy RA; Protopopova AD; Fricke TC; Lange IU; Haug FM; Nguyen PT; Gallo PN; Sousa BB; Bernardes GJL; Yarov-Yarovoy V; Leffler A; Moiseenkova-Bell VY
Nat. Commun. 2022, 13, 2334
165. Ibrutinib inhibits BMX-dependent endothelial VCAM-1 expression in vitro and pro-atherosclerotic endothelial activation and platelet adhesion in vivo
Kohs TCL; Olson SR; Pang J; Jordan KR; Zheng TJ; Xie A; Hodovan J; Muller M; McArthur C; Johnson J; Sousa BB; Wallisch M; Kievit P; Aslan JE; Seixas JD; Bernardes GJL; Hinds MT; Lindner JR; McCarty OJK; Puy C; Shatzel JJ
Cel. Mol. Bioeng. 2022, 15, 231–243
164. Single mutation on Trastuzumab modulates the stability of antibody-drug conjugates built using acetal-based linkers and thiol-maleimide chemistry
Ferhati X; Jiménez-Moreno E; Hoyt EA; Salluce G; Cabeza-Cabrerizo M; Navo CD: Compañón I; Akkapeddi P; Matos MJ; Salaverri N; Garrido P; Martínez A; Laserna V; Murray TV; Jiménez-Osés G; Ravn P; Bernardes GJL*; Corzana F*
J. Am. Chem. Soc. 2022, 144, 5284–529
163. Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates
Carboni F; Kitowski A; Sorieul C; Veggi D; Marques MC; Oldrini D; Balducci E; Brogioni B; Del Bino L; Corrado A; Angiolini F; Dello Iacono L; Margarit I; Romano MR; Bernardes GJL*; Adamo R*
Chem Sci., 2022, 13, 2440–2449
162. Transition metal mediated bioorthogonal release
Sabatino V; Unnikrishnan VB; Bernardes GJL*
Chem Catal., 2022, 2, 39–51
161. Controlled in-cell generation of active palladium(0) species for bioorthogonal decaging
Konč J; Sabatino V; Jiménez-Moreno E; Latocheski E; Rodríguez Pérez L; Day J; Domingos JB; Bernardes GJL*
Angew. Chem. Int. Ed. 2022, e202113519
Selected as a Hot Paper.
160. A structural ensemble of a Tau-microtubule complex reveals regulatory Tau phosphorylation and acetylation mechanisms
Faidon Brotzakis Z; Lindstedt PR; Taylor RJ; Rinauro DJ; Gallagher NCT; Bernardes GJL; Vendruscolo M*
ACS Cent. Sci. 2021, 7, 1986−1995
159. Bioorthogonal self-immolative linker based on Grob fragmentation
Ferhati X; Salas-Cubero M; Garrido P; García-Sanmartín J; Guerreiro A; Avenoza A; Busto JH; Peregrina JM; Martínez A; Jiménez-Moreno E*; Bernardes GJL*; Corzana F*
Org. Lett. 2021, 23, 8580−8584
158. Diazaborines are a versatile platform to develop ROS responsive antibody drug conjugates
António JPM; Carvalho JI; André AS: Dias JNR; Aguiar SI; Faustino H; Lopes RMRM; Veiros LF; Bernardes GJL; da Silva FA; Gois PMP*
Angew. Chem. Int. Ed. 2021, 60, 25914–25921
157. A platform for site-specific DNA-antibody bioconjugation by using benzoylacrylic-labelled oligonucleotides
Konč J; Brown J; Whiten DR; Zuo Y; Ravn P; Klenerman D; Bernardes GJL*
Angew. Chem. Int. Ed. 2021, 60, 25905–25913
156. Accelerating reaction rates of biomolecules by using shear stress in artificial capillary systems
Hakala TA; Yates EV; Challa PK; Toprakcioglu Z; Nadendla K; Matak-Vinkovic D; Dobson CM; Martínez R; Corzana F*; Knowles TPJ*; Bernardes GJL*
J. Am. Chem. Soc. 2021, 143, 16401–16410
Highlighted in Chemistry World, “Tiny mechanical forces deform proteins in living systems for faster reactions”; in In The Pipeline, "Pushing Through the Capillaries"; and in Nature Chemical Biology, "Catalysis under stress".
155. Dichloro butendiamides as irreversible site-selective protein conjugation reagent
Laserna V*; Abegg D; Afonso CF; Martin EM; Adibekian A; Ravn P; Corzana F; Bernardes GJL*
Angew. Chem. Int. Ed. 2021, 60, 23750–23755
Selected as a Hot Paper.
154. Combating small-molecule aggregation with machine learning
Lee K; Yang A; Lin Y-C; Reker D; Bernardes GJL; Rodrigues T
Cell. Rep. Phys. Sci. 2021, 2, 100573
153. Arylethynyltrifluoroborate dienophiles for on demand activation of IEDDA reactions
Zawada Z; Guo Z; Oliveira BL; Navo CD; Li H; Cal PMSD; Corzana F; Jiménez-Osés G*; Bernardes GJL*
Bioconjugate Chem. 2021, 32, 1812−1822
152. METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation