ALL PUBLICATIONS
For citation analysis and h-index, check my Google Scholar.
195. Gold(III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-Acid Mediated Allyl Substitution.
V B Unnikrishnan; Sabatino V; Amorim F; Estrada MF; Navo CD; Jimenez-Oses G; Fior R; Bernardes GJL*
J. Am. Chem. Soc. 2024, 146, 23240–23251.
194. Non-natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity.
Guerreiro A, Compañón I, Lazaris FS, Labão-Almeida C, Oroz P, Ghirardello M, Marques MC, Corzana F, Bernardes GJL*
Angew. Chem. Int. Ed. 2024 Accepted for publication.
193. Small Molecule RNA Degraders.
Bonet–Aletaa J; Maeharaa T; Craig BA; Bernardes GJL*
Angew. Chem. Int. Ed. 2024, Accepted for publication.
192. Proximity-driven Site-specific Cyclization of Phage-displayed Peptides.
Brown L; Vasco Vidal A; Laura Dias A; Rodrigues T; Sigurdardottir A; Journeaux T; O’Brien S; Murray TV; Ravn P; Papworth M; Bernardes GJL*
Nature Communications 2024, 15, 7308.
191. On-demand thio-succinimide hydrolysis for the assembly of stable protein–protein conjugates.
Vasco AV; Taylor RJ; Méndez Y; Bernardes GJL*
J Am Chem Soc. 2024, 146, 20709–20719.
190. Designed Endocytosis Inducing Proteins Degrade Targets and Amplify Signals.
Huang B; Abedi M; Ahn G; Coventry B; Sappington I; Tang C; Wang R; Schlichthaerle T; Zhang JZ; Wang Y; Goreshnik I; Wen Chiu C; Chazin-Gray A; Chan S; Gerben S; Murray A; Wang S; O'Neill J; Yi L; Yeh R; Misquith A; Wolf A; Tomasovic LM; Piraner DI; Duran Gonzalez MJ; Bennett NR; Venkatesh P; Ahlrichs M; Dobbins C; Yang W; Wang X; Sahtoe D; Vafeados D; Mout R; Shivaei S; Cao L; Carter L; Stewart L; Spangler JB; Roybal KT; Jr. Greisen P; Li X; Bernardes GJL; Bertozzi CR; Baker D (senior co-author)
Nature 2024, Accepted for publication
189. Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin−Drug Conjugates.
Bernardim B, Conde J, Hakala T, Becher JB, Canzano M, Vasco AV, Knowles TPJ, Cameron J, BernardesGJL*
Bioconjugate Chem.2024, 35, 132–139.
Featured as an ACS Editors' Choice.
188. Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms.
Mikutis S, Lawrinowitz S, Kretzer C, Dunsmore L, Sketeris L, Rodrigues T, Werz O, Bernardes GJL
ACS Chem Biol. 2024 19, 217–229
187. Homogeneous Multi-Payload Antibody Drug Conjugates
Journeaux T; Bernardes GJL*
Nature Chemistry 2024, 16, 854–870.
186. A Structure-Guided Approach for the Development of MUC1-Glycopeptide- Based Cancer Vaccines with Predictable Responses
Bermejo IA; Guerreiro A; Eguskiza A; Martínez-Sáez N; Lazaris FS; Asín A; Somovilla VJ; Compañón I; Raju TK; Tadic S; Garrido P; García-Sanmartín J; Mangini V; Grosso AS; Marcelo F; Avenoza A; Busto JH; García-Martín F; Hurtado-Guerrero R; Peregrina JM; Bernardes GJL*; Martínez A*; Fiammengo R*; Corzana F* (*senior co-authors)
JACS Au 2024, 4, 150–163.
185. Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1
Luís A. R. Carvalho LAR; Sousa BB; Zaidman D; Kiely-Collins H, Bernardes GJL*
ChemBioChem 2024, e202300736.
184. Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores
Sandler SE; Horne RI; Rocchetti S; Novak R; Hsu NS; Castellana Cruz M; Faidon Brotzakis Z; Gregory RC; Chia S; Bernardes GJL; Keyser UF; Vendruscolo M
J Am Chem Soc. 2023,145, 25776–25788
183. Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules
Mikutis S*; Rebelo M; Yankova E; Gu M; Tang C; Coelho AR; Yang M; Hazemi ME; Miranda MP; Eleftheriou M; Robertson M; Vassiliou GS; Adams DJ; Simas JP; Corzana F; Schneekloth Jr. JS; Tzelepis K*; Bernardes GJL*
ACS Cent. Sci. 2023, 9, 5, 892–904
182. Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions
TForno GM; Latocheski E; Machado AB; Becher J; Dunsmor L; St. John AL; Oliveira BL; Navo CD; Jiménez-Osés G; Fior R; Domingos JB*; Bernardes GJL*
J. Am. Chem. Soc. 2023, 145, 19, 10790–10799
181. Merging the isonitrile-tetrazine (4+1) cycloaddition and the Ugi four-components reaction into a single multicomponent process
Méndez Y; Vasco AV; Ivey G; Dias AL; Gierth P; Sousa BB; Navo CD; Torres-Mozas A; Rodrigues T;
Jiménez-Osés G; Bernardes GJL*
Angew. Chem. Int. Ed. 2023, e202311186
180. De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Rebelo M; Tang C; Coelho AR; Labão-Almeida C; Schneider MM; Tatalick L; Ruivo P; de Miranda MP;
Gomes A; Carvalho T; Walker MJ; Ausserwoeger H; Pedro Simas J; Veldhoen M; Knowles TPJ; Silva
DA; Shoultz D; Bernardes GJL*
J. Infect. Dis. 2023, 228, 723–733
179. Unlocking the Potential of Bio-Based Nitrogen-Rich Furanic Platforms as Biomass Synthons
Gomes RFA*; Gonçalves BMF; Andrade KHS; Sousa BB; Maulide N; Bernardes GJL*, Afonso CAM*
Angew. Chem. Int. Ed. 2023, 62, e202304449
178. Clinical and pre-clinical utility of click chemistry
Mikutis S; Bernardes GJL*
Cell 2023, 186, 3, 662 - 662.E1
177. A Selective SARS-CoV‑2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species
Tang C; Coelho AR; Rebelo M; Kiely-Collins H; Carvalho T; Bernardes GJL*
ACS Cent. Sci. 2023, 9, 1, 109–121
176. Strategies for Conditional Regulation of Proteins
Nadendla K, Simpson CG, Becher J, Journeaux T, Cabeza-Cabrerizo M, Bernardes GJL*
JACS Au 2023, 3, 2, 344–357
175. Introducing the 2023 Bioconjugate Chemistry Editorial Team.
Bernardes GJL, Zou P, Dai Z, Lavik E, van Hest J, Zheng G, Quinn N, MacLaughlin CM, Reineke TMTang C; Coelho AR; Rebelo M; Kiely-Collins H; Carvalho T;
Bioconjug Chem. 2023, 34, 279–282
174. Fragment-based computational design of antibodies targeting structured epitopes
Rangel MA; Bedwell A; Costanzi E; Taylor RJ; Russo R; Bernardes GJL; Ricagno S; Frydman J; Vendruscolo M*; Sormanni P*
Sci. Adv. 2022, 8, eabp9540
173. Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors
Sousa BB; Almeida CR; Barahona AF; Lopes R; Martins-Logrado A; Cavaco M; Neves V; Carvalho LAR; Labão-Almeida C; Coelho AR; Bento ML; Lopes RMRM; Oliveira BL; Castanho MARB; Neumeister P; Deutsch A; Vladimer GI; Krall N; João C; Corzana F; Seixas JD; Fior R, Bernardes GJL*
ACS Pharmacol. Transl. Sci. 2022, 5, 11, 1156–1168
172. Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones
Afonso CF; Marques MC; António JPM; Cordeiro C; Gois PMP; Cal PMSD; Bernardes GJL*
Angew. Chem. Int. Ed. 2022, 61, e202208543
Selected as a Hot Paper.
171. π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation
Taylor RJ; Rangel MA; Geeson MB; Sormanni P; Vendruscolo M; Bernardes GJL*
J. Am. Chem. Soc. 2022, 144, 14404–14419
170. The impact of activity-based protein profiling in malaria drug discovery
Carvalho LAR*; Bernardes GJL*
ChemMedChem 2022, 17, e202200174
169. Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination
Dunsmore L; Navo CD; Becher J; Gil de Montes E; Guerreiro A; Hoyt E; Brown L; Zelenay V; Mikutis S; Cooper J; Barbieri I; Lawrinowitz S; Siouve E; Martin E; Ruivo PR; Rodrigues T; da Cruz FP; Werz O; Vassiliou G; Ravn P; Jiménez-Osés G*; Bernardes GJL*
Nat. Chem. 2022, 14, 754–765
168. Platform for orthogonal N-cysteine-specific protein modification enabled by cyclopropenone reagents
Istrate A; Geeson MB; Navo CD; Sousa BB; Marques MC; Taylor RJ; Journeaux T; Oehler SR; Mortensen MR; Deery MJ; Bond AD; Corzana F; Jiménez-Osés G*; Bernardes GJL*
J. Am. Chem. Soc. 2022, 144, 10396–10406
167. Chemical and enzymatic methods for post-translational protein–protein conjugation
Taylor RJ; Geeson MB; Journeaux T; Bernardes GJL*
J. Am. Chem. Soc. 2022, 144, 14404–14419
166. Structural insights into TRPV2 activation by small molecules
Pumroy RA; Protopopova AD; Fricke TC; Lange IU; Haug FM; Nguyen PT; Gallo PN; Sousa BB; Bernardes GJL; Yarov-Yarovoy V; Leffler A; Moiseenkova-Bell VY
Nat. Commun. 2022, 13, 2334
165. Ibrutinib inhibits BMX-dependent endothelial VCAM-1 expression in vitro and pro-atherosclerotic endothelial activation and platelet adhesion in vivo
Kohs TCL; Olson SR; Pang J; Jordan KR; Zheng TJ; Xie A; Hodovan J; Muller M; McArthur C; Johnson J; Sousa BB; Wallisch M; Kievit P; Aslan JE; Seixas JD; Bernardes GJL; Hinds MT; Lindner JR; McCarty OJK; Puy C; Shatzel JJ
Cel. Mol. Bioeng. 2022, 15, 231–243
164. Single mutation on Trastuzumab modulates the stability of antibody-drug conjugates built using acetal-based linkers and thiol-maleimide chemistry
Ferhati X; Jiménez-Moreno E; Hoyt EA; Salluce G; Cabeza-Cabrerizo M; Navo CD: Compañón I; Akkapeddi P; Matos MJ; Salaverri N; Garrido P; Martínez A; Laserna V; Murray TV; Jiménez-Osés G; Ravn P; Bernardes GJL*; Corzana F*
J. Am. Chem. Soc. 2022, 144, 5284–529
163. Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates
Carboni F; Kitowski A; Sorieul C; Veggi D; Marques MC; Oldrini D; Balducci E; Brogioni B; Del Bino L; Corrado A; Angiolini F; Dello Iacono L; Margarit I; Romano MR; Bernardes GJL*; Adamo R*
Chem Sci., 2022, 13, 2440–2449
162. Transition metal mediated bioorthogonal release
Sabatino V; Unnikrishnan VB; Bernardes GJL*
Chem Catal., 2022, 2, 39–51
161. Controlled in-cell generation of active palladium(0) species for bioorthogonal decaging
Konč J; Sabatino V; Jiménez-Moreno E; Latocheski E; Rodríguez Pérez L; Day J; Domingos JB; Bernardes GJL*
Angew. Chem. Int. Ed. 2022, e202113519
Selected as a Hot Paper.
160. A structural ensemble of a Tau-microtubule complex reveals regulatory Tau phosphorylation and acetylation mechanisms
Faidon Brotzakis Z; Lindstedt PR; Taylor RJ; Rinauro DJ; Gallagher NCT; Bernardes GJL; Vendruscolo M*
ACS Cent. Sci. 2021, 7, 1986−1995
159. Bioorthogonal self-immolative linker based on Grob fragmentation
Ferhati X; Salas-Cubero M; Garrido P; García-Sanmartín J; Guerreiro A; Avenoza A; Busto JH; Peregrina JM; Martínez A; Jiménez-Moreno E*; Bernardes GJL*; Corzana F*
Org. Lett. 2021, 23, 8580−8584
158. Diazaborines are a versatile platform to develop ROS responsive antibody drug conjugates
António JPM; Carvalho JI; André AS: Dias JNR; Aguiar SI; Faustino H; Lopes RMRM; Veiros LF; Bernardes GJL; da Silva FA; Gois PMP*
Angew. Chem. Int. Ed. 2021, 60, 25914–25921
157. A platform for site-specific DNA-antibody bioconjugation by using benzoylacrylic-labelled oligonucleotides
Konč J; Brown J; Whiten DR; Zuo Y; Ravn P; Klenerman D; Bernardes GJL*
Angew. Chem. Int. Ed. 2021, 60, 25905–25913
156. Accelerating reaction rates of biomolecules by using shear stress in artificial capillary systems
Hakala TA; Yates EV; Challa PK; Toprakcioglu Z; Nadendla K; Matak-Vinkovic D; Dobson CM; Martínez R; Corzana F*; Knowles TPJ*; Bernardes GJL*
J. Am. Chem. Soc. 2021, 143, 16401–16410
Highlighted in Chemistry World, “Tiny mechanical forces deform proteins in living systems for faster reactions”; in In The Pipeline, "Pushing Through the Capillaries"; and in Nature Chemical Biology, "Catalysis under stress".
155. Dichloro butendiamides as irreversible site-selective protein conjugation reagent
Laserna V*; Abegg D; Afonso CF; Martin EM; Adibekian A; Ravn P; Corzana F; Bernardes GJL*
Angew. Chem. Int. Ed. 2021, 60, 23750–23755
Selected as a Hot Paper.
154. Combating small-molecule aggregation with machine learning
Lee K; Yang A; Lin Y-C; Reker D; Bernardes GJL; Rodrigues T
Cell. Rep. Phys. Sci. 2021, 2, 100573
153. Arylethynyltrifluoroborate dienophiles for on demand activation of IEDDA reactions
Zawada Z; Guo Z; Oliveira BL; Navo CD; Li H; Cal PMSD; Corzana F; Jiménez-Osés G*; Bernardes GJL*
Bioconjugate Chem. 2021, 32, 1812−1822
152. METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation