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GBernardesLab
95. Radical-mediated thiol-ene strategy for photoactivation of thiol-containing drugs in cancer cells
Sun S; Oliveira BL; Jiménez-Osés G; Bernardes GJL*
Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201811338.
94. Efficient and irreversible antibody-cysteine bioconjugation using carbonylacrylic reagents
Bernardim B; Matos MJ; Ferhati X; Compañón I; Guerreiro A; Akkapeddi P; Burtoloso ACB; Jiménez-Osés G; Corzana F; Bernardes GJL*
Nature Protoc. 2018, Accepted for publication.
93. Posttranslational chemical mutagenesis: to reveal the role of non-catalytic cysteine residues in pathogenic bacterial phosphatases
Bertoldo JB; Terenzi H; Hüttelmaier S; Bernardes GJL*
Biochemistry 2018, DOI:10.1021/acs.biochem.8b00639.
92. Lysine bioconjugation on native albumin with a sulfonyl acrylate reagent
Matos MJ; Jiménez-Osés G; Bernardes GJL*
Meth. Mol. Biol. 2018, Accepted for publication.
91. Bioorthogonal Decaging Reactions for Targeted Drug Activation
Davies D; Stenton BJ; Bernardes GJL*
Chimia 2018, Accepted for publication.
90. Modular pore-forming immunotoxins with caged cytotoxicity tailored by directed evolution
Mutter NL; Soskine M; Huang G; Albuquerque IS; Bernardes GJL; Maglia G
ACS Chem. Biol. 2018, DOI:10.1021/acschembio.8b00720.
89. Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
Rodrigues T; Werner M; Roth J; da Cruz EHG; Marques MC; Akkapeddi P; Lobo SA; Koeberle A; Corzana F; da Silva Júnior EN; Werz O; Bernardes GJL*
Highlighted in Chemistry World 2018, July 26, 2018 “Artificial intelligence seeks out new anticancer drugs”
88. A Thioether-directed Palladium-cleavable Linker for Targeted Bioorthogonal Drug Decaging
Stenton BJ; Oliveira BL; Matos MJ; Sinatra L; Bernardes GJL*
Chem. Sci. 2018, 9, 4185 - 4189.
87. Chemo and regioselective lysine modification on native proteins
Matos MJ; Oliveira BL; Martínez-Sáez N; Guerreiro A; Cal PMSD; Bertoldo J; Maneiro M; Perkins E; Howard J; Deery MJ; Chalker JM; Corzana F; Jiménez-Osés G; Bernardes GJL*
J. Am. Chem. Soc. 2018, 140, 4004-4017.
Highlighted in Chemical&Engineering News, 2018, Volume 96, Issue 11, p. 13, March 12, 2018 “Computer-designed reagent targets lysine for protein modification”; Phys.org “How to spark a chemical chain reaction”, March 9, 2018.
86. Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors
Robke L; Rodrigues T; Schröder P; Foley DJ; Bernardes GJL; Laraia L; Waldmann H
Tetrahedron 2018, 74, 4531–4537.
85. Development of antibody-directed therapies: quo vadis?
Rodrigues T; Bernardes GJL*
Angew. Chem. Int. Ed. 2018, 57, 2032-2034.
84. Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates
Matos MJ; Labão-Almeida C; Sayers C; Dada O; Tacke M; Bernardes GJL*
83. Site-selective installation of an electrophilic handle on proteins for bioconjugation
Lee B; Sun S; Jiménez-Moreno E; Neves AA; Bernardes GJL*
82. Enhanced permeability and binding activity of isobutylene-grafted peptides
Sun S; Compañón I; Martínez-Sáez N; Seixas JD; Omar Boutureira O; Corzana F;Bernardes GJL*
81. Sustainable Polysulfides for Oil Spill Remediation: Repurposing Industrial Waste for Environmental Benefit
Worthington MJH; Shearer CJ; Esdaile LJ; Campbell JA; Gibson CT; Legg SK; Yin Y; Lundquist NA; Gascooke JR; Albuquerque IS; Shapter JG; Andersson GG; Lewis DA; Bernardes GJL; Chalker JM
Adv. Sustain. Sys. 2018, 2, 1800024
Highlighted in The Guardian Researchers create super sponge that mops up oil spills
80. Norbornene probes for the study of cysteine oxidation
Alcock LJ; Farrell KD; Akol MT; Jones GH; Tierney MM; Kramer HB; Pukala TL; Bernardes GJL; Perkins MV; Chalker JM
79. A silicon-labelled amino acid suitable for late-stage fluorination and unexpected oxidative cleavage reactions in the preparation of a key intermediate in the Strecker synthesis
Scroggie KR; Alcock LJ; Matos MJ;Bernardes GJL; Perkins MV; Chalker JM
78. Chemoselective Installation of Amine Bonds on Proteins Through Aza-Michael Ligation
Freedy AM; Matos MJ; Omar Boutureira O; Corzana F; Guerreiro A; Somovilla VJ; Rodrigues T; Nicholls K; Xie B; Jiménez-Osés G; Brindle KM; Neves AA; Bernardes GJL*
77. The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer
Somovilla VJ;‡ Bermejo IA;‡ Albuquerque IS;‡ Martínez-Sáez N; Castro-López J; García-Martín F; Compañón I; Hinou H; Nishimura S-I; Jiménez-Barbero J; Asensio JL; Avenoza A; Busto JH; Hurtado-Guerrero R; Peregrina JM; Bernardes GJL;* Corzana F* (*co-senior authors)
J. Am. Chem. Soc.2018, 139, 18255–18261.
Featured in JACS Spotlights
76. Oxetane grafts site-selectively installed on native disulfides enhance protein stability and activity in vivo
Martínez-Sáez N; Sun S; Oldrini D; Sormanni P; Boutureira O; Carboni F; Compañón I; Deery MJ; Vendruscolo M; Corzana F; Adamo R; Bernardes GJL*
75. Post-expression regioselective mutagenesis reveals a water-bridged cysteine–cysteine redox regulation mechanism in bacterial protein tyrosine phosphatases
Bertoldo JB; Rodrigues T; Dunsmore L; Aprile FA; Marques MC; Rosado L; Boutureira O; Steinbrecher TB; Sherman W; Corzana F; Terenzi H; Bernardes GJL*
74. Oxidative Activation of C–S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides
Kitowski A; Jiménez-Moreno E; Salvadó M; Mestre J; Castillón S; Jiménez-Osés G; Boutureira O; Bernardes GJL*
73. In situ characterization of advanced glycation end products (AGEs) in collagen and model extracellular matrix by solid state NMR
Li R; Rajan R; Wong WCV; Reid DG; Duer MJ; Somovilla VJ; Martinez-Saez N; Bernardes GJL; Hayward R; Shanahan M
Featured on the cover
72. Nickel-Catalyzed Azide–Alkyne Cycloaddition to Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water
Kim WG; Kang ME; Lee JB; Jeon MH; Lee S; Lee J; Choi B; Cal PMSD; Kang S; Kee Jung-Min; Bernardes GJL; Rohde Jan-Uwe; Choe W; Hong SY
71. Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils
Worthington MJH; Kucera RL; Albuquerque IS; Gibson CT; Sibley A; Slattery AD; Campbell JA; Alboaiji SFK; Muller KA; Young J; Adamson N; Gascooke JR; Jampaiah D; Sabri YM; Bhargava SK; Ippolito SJ; Lewis DA; Quinton JS; Ellis AV; Johs A; Bernardes GJL, Chalker JM
Chem. Eur. J.2017, 23, 16219–16230
Selected as a Hot Paper.
Highlighted in Nature, August 2017. “Old cooking oil could be used to clean up mercury”
70. Inverse electron demand Diels–Alder reactions in chemical biology
Oliveira BL; Guo Z; Bernardes GJL*
Chem. Soc. Rev. 2017,46, 4811–5174
69. Site-selective modification of proteins with oxetanes
Boutureira O; Martínez-Sáez N; Brindle KM; Neves AA; Corzana F; Bernardes GJL*
Chem. Eur. J. 2017, 23, 6483–6489
68. Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(II) catalyst
Kwan TT-L; Boutureira O; Frye EC; Gupta MK; Wallace S; Wu Y; Zhang F; Sore HF; Galloway WRJD; Chin JW; Welch M; Bernardes GJL*; Spring DR
Chem. Sci. 2017, 8, 3871–3878
67. A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
Pereira MMA; Mahú I; Seixas E; Martinéz-Sánchez N; Kubasova N; Pirzgalska RM; Cohen P; López M; Bernardes GJL*; Domingos AI* (*co-senior authors)
Nature Communications 2017, 8, 14967
66. Vinyl ether–tetrazine pair for the traceless release of alcohols in cells
Jiménez-Moreno E; Guo Z; Oliveira BL; Albuquerque IS; Kitowski A; Guerreiro A; Boutureira O; Rodrigues T; Jiménez-Osés G; Bernardes GJL*
Angew. Chem. Int. Ed.2017, 56, 243-247
65. Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells
Cal PMSD; Sieglitz F; Santos FMF; Carvalho CP; Guerreiro A; Bertoldo JB; Pischel U; Gois PMP; Bernardes GJL*
Chem. Commun.2017, 53, 368-371
64. Trends in therapeutic drug conjugates for bacterial diseases: a patent review
Cal PMSD; Matos MJ; Bernardes GJL*
Expert Opin. Ther. Pat.2016,27, 179–189
63. Antibody-drug conjugates: The missing link
Rodrigues T; Bernardes GJL*
NatureChemistry2016, 8, 1088–1090
62. A minimal, unstrained S-allyl handle for pre-targeting Diels–Alder bioorthogonal labelling in live cells
Oliveira BL, Guo Z; Boutureira O; Guerreiro A; Jiménez-Osés G; Bernardes GJL*
Angew. Chem. Int. Ed.2016, 55, 14683 –14687
61. Stoichiometric and Irreversible Cysteine-selective Protein Modification using Carbonylacrylic Reagents
Bernardim B; Cal PMSD; Matos MJ; Oliveira BL; Martínez-Sáez N; Albuquerque IS; Corzana F; Burtoloso ACB; Jiménez-Osés G; Bernardes GJL*
Nature Communications2016, 7, 13128
60. Bioorthogonal Strategy for Bioprocessing of Specific-site-functionalized Enveloped Influenza-virus-like Particles
Carvalho SB; Freire JM; Moleirinho MG; Monteiro F; Gaspar DMD; Castanho MARB; Carrondo MJT; Alves PMA; Bernardes GJL*; Peixoto C
Bioconjugate Chem2016, 27, 2386–2399
59. Unveiling (-)-Englerin A as a modulator of L-type calcium channels
Rodrigues T; Sieglitz F; Somovilla VJ; Cal PMSD; Galione A; Corzana F; Bernardes GJL*
Angew. Chem. Int. Ed. 2016, 55, 11077-11081
58. Tn Antigen Mimics Based on sp2-Iminosugars with Affinity for an anti-MUC1 Antibody
Fernández EMS; Navo CD; Martínez-Sáez N; Gonçalves-Pereira R; Somovilla VJ; Avenoza A; Busto JH; Bernardes GJL; Jiménez-Osés G; Corzana F; García Fernández JM; Mellet CO; Peregrina JM
Org. Lett. 2016, 18, 3890–3893
57. Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation
Faustino H; Silva MJSA; Veiros LF; Bernardes GJL; Gois PMP
Chem. Sci. 2016, 7, 5052-5058
56. Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents
Rodrigues T; Sieglitz F; Bernardes GJL*
Chem. Soc. Rev. 2016, 45, 6130–6137
Emerging Investigators Issue 2016.
See contributors’ profile in : Chem. Soc. Rev. 2016, 45, 6089–6092
55. Construction of Homogeneous Antibody-drug Conjugates using Site-selective Protein Chemistry
Akkapeddi P; Azizi S-A; Freedy A; Cal PMSD; Gois PMP; Bernardes GJL*
Chem. Sci. 2016, 7, 2954-2963
54. Urban endocrine disruptors targeting breast cancer proteins
Montes-Grajales D; Bernardes GJL*; Olivero-Verbel JT
Chem. Res. Toxicol. 2016, 29, 150–161
53. Site-selective protein-modification chemistry for basic biology and drug development
Krall N; da Cruz FP; Boutureira O; Bernardes GJL*
Nature Chem. 2016, 8, 103–113
Highlighted in Nature Chem 2016, 8, 91 - A little less conjugation, a little more accuracy.
52. Sulfur-Limonene Polysulfide: A Material Synthesized Entirely from Industrial Waste and Its Use in Removing Toxic Metals from Water and Soil
Crockett MP; Evans AM; Worthington MJH; Albuquerque IS; Slattery AD; Gibson CT; Bernardes GJL, Chalker JM
Angew. Chem. Int. Ed., 2016, 55, 1714–1718
Selected as a Hot Paper.
Highlighted in Chemical&Engineering News, November 2, 2015.
51. A N-acetyl cysteine ruthenium tricarbonyl conjugate enables simultaneous release of CO and ablation of ROS species
Seixas JD; Chaves-Ferreira M; Montes-Grajales D; Gonçalves AM; Marques AR; Saraiva LM; Olivero-Verbel J; Romão CC; Bernardes GJL*
Chem. Eur. J. 2015, 21, 14708–14712
Hot Paper.
50. An artificial CO-releasing metalloprotein built by histidine-selective metallation
Albuquerque IS; Jeremias HF; Chaves-Ferreira M; Matak-Vinkovic D; Boutureira O; Romão CC; Bernardes GJL*
Chem. Commun. 2015, 51, 3993–3996
49. Advances in chemical protein modification
Boutureira O; Bernardes GJL*
Chem. Rev. 2015, 115, 2174–2195
48. Spontaneous CO Release from RuII(CO)2-Protein Complexes in Aqueous Solution, Cells and Mice
Ferreira MC; Albuquerque IS; Matak-Vinkovic D; Coelho AC; Carvalho SM; Saraiva LM; Romão CC; Bernardes GJL*
Angew. Chem. Int. Ed. 2015, 54, 1172–1175
47. Collagen labelling with an azide-proline chemical reporter in live cells
Amgarten B; Rajan R; Martínez-Sáez N; Oliveira BL; Albuquerque IS; Reid DG; Brooks RA; Duer MJ; Bernardes GJL*
Chem. Commun. 2015, 51, 5250–5252
Emerging Investigators Issue 2015.
46. Synthesis of Fluorosugar Reagents for the Construction of Well-Defined Fluoroglycoproteins
Salvadó M; Amgarten B; Castillón S; Bernardes GJL*; Boutureira O
Org. Lett. 2015, 17, 2836–2839
45. Deciphering the Non‐Equivalence of Serine and Threonine O‐Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti‐MUC1 Antibody
Martínez-Sáez N; Castro-López J; Valero-González J, Madariaga D; Compañón I; Somovilla VJ; Salvadó M; Asensio JL; Jiménez-Barbero J; Avenoza A; Busto JH; Bernardes GJL; Peregrina JM; Hurtado-Guerrero R; Corzana F
Angew. Chem. Int. Ed. 2015, 54, 9830–9834
44. Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation
Lira-Navarrete E; de las Rivas M; Compañón I; Pallarés MC; Kong Y; Iglesias-Fernández J; Bernardes GJL; Peregrina JM; Rovira C; Bernadó P; Bruscolini P; Clausen H; Lostao A; Corzana F; Hurtado-Guerrero R
Nature Commun. 2015, 6, 6937
43. Peptide anchor for folate-targeted liposomal delivery
Nogueira E; Mangialavori IC; Loureiro A; Azoia NG; Sárria MP; Nogueira P; Freitas J; Härmark J; Shimanovich U; Rollett A; Lacroix G; Bernardes GJL, Guebitz GM; Herbert H; Moreira A; Carmo AM; Rossi JPFC; Gomes AC; Preto A; Cavaco-Paulo A
Biomacromolecules 2015, 16, 2904–2910
42. Size Controlled Protein Nanoemulsions for Active Targeting of Folate Receptor Positive Cells
Loureiro A; Nogueira E; Azoia NG; Sárria MP; Abreu AS; Shimanovich U; Rollet A; Härmark J; Hebert H; Guebitz G; Bernardes GJL; Preto A; Gomes AC; Cavaco-Paulo A
Colloids Surf. B Biointerfaces 2015, 135, 90–98
41. Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice
Nogueira E; Lager F; Le Roux D; Nogueira P; Freitas J; Charvet C; Renault G; Loureiro A; Almeida CR; Ohradanova-Repic A; Machacek C; Bernardes GJL; Moreira A; Stockinger H; Burnet M; Carmo AM; Gomes AC; Preto A; Bismuth G; Cavaco-Paulo A
Biomed. Nanotechnol. 2015, 11, 2243–2252
40. Folic Acid-Tagged Protein Nanoemulsions Loaded with CORM-2 Enhance the Survival of Mice Bearing Subcutaneous A20 Lymphoma Tumors
Loureiro A; Bernardes GJL*; Shimanovich U; Sárria MP; Nogueira E; Preto A; Gomes AC; Cavaco-Paulo A
Nanomedicine 2015, 11, 1077–1083
39. A contribution to the rational design of Ru(CO)3Cl2L complexes for in vivo delivery of CO
Seixas JD; Santos MFA; Mukhopadhyay A; Coelho AC; Reis PM; Veiros LF; Marques AR; Penacho N; Gonçalves AML; Romão MJ; Bernardes GJL; Santos-Silva, T; Romão CC
Dalton Trans. 2015, 44, 5058–5075
38. Functionalized protein nanoemulsions by incorporation of chemically modified BSA
Loureiro A; Abreu AS; Sárria MP; Figueiredo MCO; Saraiva LM; Bernardes GJL; Gomes AC; Cavaco-Paulo A
RSC Advances 2015, 5, 4976–4983
37. Highlights from the 49th EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2014
Bernardes GJL*; Lawrence AL
Chem. Commun. 2014, 50, 10752–10757
36. Cysteine Selective Reactions for Antibody Conjugation
Cal PMSD; Bernardes GJL*; Gois PMP
Angew. Chem. Int. Ed. 2014, 53, 10585–10587
35. Carbon-monoxide releasing molecules for the delivery of therapeutic CO in vivo
García-Gallego S; Bernardes GJL*
Angew. Chem. Int. Ed. 2014, 53, 9712–9721
34. Protein Micro and Nano Capsules for Biomedical Applications
Shimanovich U; Bernardes GJL*, Knowles TJ; Cavaco-Paulo A
Chem. Soc. Rev. 2014, 43, 1361–1371
33. Highlights from the 48th EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2013
Bernardes GJL*
Chem. Commun. 2013, 49, 8578–8582
32. Synthetically defined glycoprotein vaccines: Current status & future directions
Adamo D; Nilo A; Castagner B; Boutureira O; Berti F; Bernardes GJL*
Chem. Sci. 2013, 4, 2995–3008
EMBO Fellow with Prof. Dario Neri
31. A Small Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors
Krall N; Pretto, F; Decurtins W; Bernardes GJL; Supuran CT; Neri D
Angew. Chem. Int. Ed. 2014, 53, 4231–4235
30. Curative Properties of Non-Internalizing Antibody-Drug Conjugates Based on Maytansinoids
Perrino E; Steiner M; Krall N; Bernardes GJL; Pretto F; Casi G; Neri D
Cancer Res. 2014, 74, 2569–2578
29. Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature
Steiner M; Hartmann I; Perrino E; Casi G; Brighton S; Jelesarov I; Bernardes GJL*; Neri D
Chem. Sci. 2013, 4, 297–302
28. Site-specific Chemical Modification of Antibody Fragments with Traceless Cleavable Linkers
Bernardes GJL; Steiner M; Hartmann I; Neri D; Casi G
Nature Protoc. 2013, 8, 2079–2089
27. Fucose-specific Conjugation of Hydrazide Derivatives to a Vascular-targeting Monoclonal Antibody in IgG Format”
Zuberbühler K; Casi G; Bernardes GJL; Neri D
Chem. Commun. 2012, 48, 7100–7102
26. A Traceless Vascular Targeting Antibody-Drug Conjugate for Cancer Therapy
Bernardes GJL; Casi G; Trüssel S; Hartmann I; Schwager K; Scheuermann J; Neri D
Angew. Chem. Int. Ed. 2012, 51, 941–944
Very Important Paper (VIP).
Highlighted in Chimia 2012, 66, 130; ETH Life – “Starving Cancer”.
Group Leader at the biotechnology company Alfama Lta.
25. Generation of liver specific carbon monoxide-releasing molecule (CO-RM) as drug candidates for the treatment of acute liver injury: targeting of CO-RMs to the liver
Marques AR; Kromer L; Gallo DJ; Penacho NM; Rodrigues SS; Seixas JD; Bernardes GJL; Reis PM; Otterbein SL; Ruggieri RA; Gonçalves ASG; Gonçalves AML; De Matos MN; Bento I; Otterbein LE; Blättler WA; Romão CC
Organometallics 2012, 31, 5810-5822
Special issue Organometallics in Biology and Medicine.
24. Developing Drug Molecules for Therapy with Carbon Monoxide
Romão CC; Seixas JD; Blättler WA; Bernardes GJL*
Chem. Soc. Rev. 2012, 41, 3571–3583
23. A Novel CO-releasing Molecule Fully Protects Mice from Severe Malaria
Pena AC; Penacho N; Mancio da Silva L; Neres R; Seixas JD; Fernandes AC; Romão CC; Mota MM; Bernardes GJL*; Pamplona A
Antimicrob. Agents Chemother. 2012, 56, 1281–1290
22. Towards Improved Therapeutic CORMs: Understanting the Reactivity of CORM-3 with Proteins
Santos-Silva T; Mukhopadkyay A; Seixas JD; Bernardes GJL; Romão CR; Romão MJ
Curr. Med. Chem. 2011, 18, 3361–3366
21. CORM-3 Reactivity Towards Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysosyme Complex
Santos-Silva T; Mukhopadkyay A; Seixas JD; Bernardes GJL*; Romão CR; Romão MJ
J. Am. Chem. Soc. 2011, 133, 1192–1195
Marie-Curie Fellow with Prof. Peter Seeberger
20. Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting
Bernardes GJL; Kikkeri R; Maglinao M; Laurino P; Collot M; Hong SY; Lepenies B; Seeberger PH
Org. Biomol. Chem. 2010, 8, 4987-4996
Hot Article.
19. Combined Approaches to the Synthesis and Study of Glycoproteins
Bernardes GJL; Castagner B; Seeberger PH
ACS Chem. Biol. 2009, 4, 703–713
Most accessed articles from ACS Chemical Biology in 2009.
D.Phil. with Prof. Ben Davis
18. Precise Probing of Residue Roles by Post-translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites
Dadová J; Wu K-J; Isenegger PG; Errey JC; Bernardes GJL, Chalker JM; Raich K; Rovira C; Davis BG
ACS Cent. Sci. 2017, 3, 1168–1173
17. Post-translational mutagenesis: a chemical strategy for exploration of protein side-chain diversity
Wright TH; Bower BJ; Chalker JM; Bernardes GJL; Wiewiora R; Ng WL; Raj R; Faulkner S; Vallée MRJ; Phanumartwiwath A; Coleman OD; Thézénas ML; Khan M; Galan SRG; Lercher L; Schombs MW; Gerstberger S; Palm-Espling ME; Baldwin MJ; Kessler BM; Claridge TDW; Mohammed S; Davis BG
Science 2016, 354, 597
Highlight in Science 2016, 354, 553–554; Chemical&Engineering News, September 26, 2016; Nature Methods 2016, 13, 907.
16. Rationally Designed Short Polyisoprenol-linked PglB Substrates for Engineered Polypeptide N-Glycosylation
Liu F; Vijayakrishnan B; Faridmoayer A; Taylor TA; Parsons TB; Bernardes GJL; Kowarik M; Davis BG
J. Am. Chem. Soc. 2014, 15, 566–569
15. SeS-linked Homogeneous Glycopeptides and Glycoproteins: Synthesis of Human Hepatic ‘Se-Metabolite A’
Boutureira O; Bernardes GJL; Fernández-González M; Davis BG
Angew. Chem. Int. Ed. 2012, 51, 1432–1436
14. Direct Radiolabelling of Proteins at Cysteine using [18F]-fluorosugars
Boutureira O; Bernardes GJL; D’Hooge F; Davis BG
Chem. Commun. 2011, 30, 10010–10012
13. Methods for the Conversion of Cysteine to Dehydroalanine on Peptides and Proteins
Chalker JM; Gunnoo SB; Boutureira O; Gerstberger SC; Fernández-González M; Bernardes GJL; Griffin L; Hailu H; Schofield CJ; Davis BG
Chem. Sci. 2011, 2, 1666–1676
Featured on the Cover.
12. A “Tag-and-Modify” Approach to Site-selective Protein Modification
Chalker JM; Bernardes GJL; Davis BG
Acc. Chem. Res. 2011, 44, 730–741
Special issue on Bioorthogonal Chemistry in Biology.
11. Site-selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations
Bernardes GJL; Linderoth L; Doores KJ; Boutureira O; Davis BG
ChemBioChem 2011, 12, 1383–1386
Most accessed articles from ChemBioChem in 2011.
10. A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates
Grayson EJ; Bernardes GJL; Chalker JM; Boutureira O; Koeppe JR; Davis BG
Angew. Chem. Int. Ed. 2011, 50, 4127–4132
9. Site-selective chemoenzymatic construction of synthetic glycoproteins using endoglycosidases
Fernández-González M; Boutureira O; Bernardes GJL; Chalker JM; Young MA; Errey JC; Davis BG
Chem. Sci. 2010, 1, 709–715
8. Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins
Boutureira O; D’Hooge F; Fernández-González M; Bernardes GJL; Sánchez-Navarro M; Koeppe JR; Davis BG
Chem. Commun. 2010, 46, 8142–8144
Hot Article and featured on the Cover.
7. Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology
Chalker JM; Bernardes GJL; Lin AY; Davis BG
Chem. Asian J., 2009, 4, 630–640
Most accessed articles from Chem. Asian J. in 2009 and 2010.
6. Allyl Sulfides are Priviliged Substrates in aqueous Olefin Cross-Metathesis: Application to Site-selective Protein Modification
Lin AY; Chalker JM; Floyd N; Bernardes GJL; Davis BG
J. Am. Chem. Soc. 2008, 130, 9642–9643
Highlighted in Chemical&Engineering News, July 14, 2008; Nature Chem. Biol. 2008, 4, 527; Chemistry World, 2008, 5, 20; Faculty of 1000 Biology.
5. Chemical Site-Selective Prenylation of Proteins
Gamblin DP; van Kasteren SI; Bernardes GJL; Chalker JM; Oldham NJ; Fairbanks AJ; Davis BG
Mol. BioSyst. 2008, 4, 558–561
4. Facile Conversion of Cysteine and AlkylCysteines to Dehydroalanine: Versatile and Switchable Access to Functionalized Proteins
Bernardes GJL; Chalker, JM; Errey JC; Davis BG
J. Am. Chem. Soc. 2008, 130, 5052–5053
Highlighted in Nature Chem. Biol. 2008, 4, 527–528; Chemical&Engineering News, March 31, 2008; Chemistry World, 2008, 5, 20; Chem. Commun. 2008, 6441.
3. From Disulfide- to Thioether-linked Glycocoproteins
Bernardes GJL; Grayson EJ; Thompson S; Chalker JM; Errey JC; Oualid FE; Claridge TDW; Davis BG
Angew. Chem. Int. Ed. 2008, 47, 2244–2247
Highlighted in Angew. Chem. Int. Ed. 2008, 47, 5496-5499.
2. A Trisulfide-linked Glycoprotein
Bernardes GJL; Marston JP; Batsanov AS; Howard JAK; Davis BG
Chem. Commun. 2007, 3145–3147
1. The Direct Formation of Glycosyl Thiols from Reducing Sugars Allows One-pot Protein Glycoconjugation
Bernardes GJL; Gamblin DP; Davis BG
Angew. Chem. Int. Ed. 2006, 45, 4007–4011