1. Controlled in-cell generation of active palladium(0) species for bioorthogonal decaging
Konč J; Sabatino V; Jiménez-Moreno E; Latocheski E; Rodríguez Pérez L; Day J; Domingos JB; Bernardes GJL*
Angew. Chem. Int. Ed. 2022, e202113519

Selected as a Hot Paper

Paper 1

2. Accelerating reaction rates of biomolecules by using shear stress in artificial capillary systems
Hakala TA; Yates EV; Challa PK; Toprakcioglu Z; Nadendla K; Matak-Vinkovic D; Dobson CM; Martínez R; Corzana F*; Knowles TPJ*; Bernardes GJL*
J. Am. Chem. Soc. 2021, 143, 16401–16410

Highlighted in Chemistry World, “Tiny mechanical forces deform proteins in living systems for faster reactions”; in In The Pipeline, "Pushing Through the Capillaries"; and in Nature Chemical Biology, "Catalysis under stress".

Paper 2

3. Dichloro butendiamides as irreversible site-selective protein conjugation reagent
Laserna V*; Abegg D; Afonso CF; Martin EM; Adibekian A; Ravn P; Corzana F; Bernardes GJL*
Angew. Chem. Int. Ed. 2021, 60, 23750–23755

Selected as a Hot Paper.

Paper 3

4. meCLICK-Seq, a substrate-hijacking and RNA degradation strategy for the study of RNA methylation
Mikutis S; Gu M; Sendinc E; Hazemi M; Kiely-Collins H; Aspris D; Vassiliou G; Shi Y; Tzelepis K; Bernardes GJL*
ACS Cent. Sci. 2020, 6, 2196−2208

Highlighted in First ReactionsGlobal Detection of RNA Methylation by Click Degradation
Highlighted in C&ENNew system cuts RNA using only small molecules
Featured in the J. Am. Chem. Soc. virtual issue "RNA chemistry"

Paper 4

5. Adaptive Optimization of Chemical Reactions with Minimal Experimental Information
Reker D; Hoyt EA; Bernardes GJL*; Rodrigues T*
Cell Rep. Phys. Sci. 2020, 1, 100247

Highlighted in Chemistry WorldMachine-learning software competes with human experts to optimise organic reactions
Listed in Cell Rep. Phys. Sci. in the “Best of 2020” collection

Paper 5