Dr Marta Marques
FCT Postdoctoral Researcher
E-mail: martamarques@medicina.ulisboa.pt

I am a FCT-MES (PT) Postdoctoral Research Fellow in the GBernardes Lab, at Instituto de Medicina Molecular (IMM), in Lisbon. I bring my skills in big-picture thinking, molecular biology and structural biology to bear on some of the large-scale projects being performed in the lab.

In addition to bench work, I mentor undergraduate and PhD students, and supervised MSc students. I have actively sought collaborations with academic groups and companies and I have been a member of several FCT Research Projects, (as co-PI -Intracellular Drug Delivery using Small Molecule Drug Conjugates for Prostate Cancer Therapy and PI- Drug delivery of bioactive agents through selective decaging, TzDD).

I have given numerous presentations and invited lectures at national and international conferences and I was awarded with the Portuguese Young Biophysicist Prize in 2018. My work with the GBernardes group has increased my interest in drug discovery and development and I am always looking to increase my skills and expertise in this field and become a cross-functional scientist. I aspire to make a great impact at IMM and in the field of targeted therapy, especially for cancer treatment.

Areas of expertise:
Molecular and cell biology, protein isolation and purification, spectroscopic techniques (EPR, UV-VIS, fluorescence and circular dichroism) and structural biology (X-ray) 


6. A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening
Sousa BB; Sousa MFQ; Marques MC; Seixas JD; Brito JA; Matias PM; Bernardes GJL; Roldão A
Bioprocess Biosyst. Eng. 2021, 44, 209–215

5. Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors
Seixas JD*; Sousa BB; Marques MC; Guerreiro A; Traquete R; Rodrigues T; Albuquerque IS; Sousa MFQ; Lemos AR; Sousa PMF; Bandeiras TM; Wu D; Doyle SK; Robinson CV; Koehler AN; Corzana F; Matias PM; Bernardes GJL*
RSC Chem. Biol. 2020, 1, 251–262

Highlighted in the 2021 Editors’ Choice collection

4. Overexpression of osmosensitive Ca2+-permeable channel TMEM63B promotes migration in HEK293T cells
Marques MC; Albuquerque IS; Vaz SH; Bernardes GJL*
Biochemistry 2019, 58, 2861–2866

3. One-pot stapling of interchain disulfides of antibodies using an isobutylene motif
Sun S; Akkapeddi P; Marques MC; Martínez-Sáez N; Torres VM; Cordeiro C; Boutureira O; Bernardes GJL*
Org. Biomol. Chem. 2019, 17, 2005–2012

2. Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
Rodrigues T; Werner M; Roth J; da Cruz EHG; Marques MC; Akkapeddi P; Lobo SA; Koeberle A; Corzana F; da Silva Júnior EN; Werz O; Bernardes GJL*
Chem. Sci. 2018, 9, 6889–6903

Highlighted in Chemistry World 2018, July 26 “Artificial intelligence seeks out new anticancer drugs

1. Post-expression regioselective mutagenesis reveals a water-bridged cysteine–cysteine redox regulation mechanism in bacterial protein tyrosine phosphatases
Bertoldo JB; Rodrigues T; Dunsmore L; Aprile FA; Marques MC; Rosado L; Boutureira O; Steinbrecher TB; Sherman W; Corzana F; Terenzi H; Bernardes GJL*
Chem 2017, 3, 665–677