SELECTED PAPERS

For citation analysis and h-index, check my Google Scholar.

Structural insights into TRPV2 activation by small molecules
Pumroy RA; Protopopova AD; Fricke TC; Lange IU; Haug FM; Nguyen PT; Gallo PN; Sousa BB; Bernardes GJL; Yarov-Yarovoy V; Leffler A; Moiseenkova-Bell VY
Nat. Commun. 2022, 13, 2334

TRPV2 paper image

Single mutation on Trastuzumab modulates the stability of antibody-drug conjugates built using acetal-based linkers and thiol-maleimide chemistry
Ferhati X; Jiménez-Moreno E; Hoyt EA; Salluce G; Cabeza-Cabrerizo M; Navo CD: Compañón I; Akkapeddi P; Matos MJ; Salaverri N; Garrido P; Martínez A; Laserna V; Murray TV; Jiménez-Osés G; Ravn P; Bernardes GJL*; Corzana F*
J. Am. Chem. Soc. 2022, 144, 5284–529

Trastuzumab paper image

Controlled in-cell generation of active palladium(0) species for bioorthogonal decaging
Konč J; Sabatino V; Jiménez-Moreno E; Latocheski E; Rodríguez Pérez L; Day J; Domingos JB; Bernardes GJL*
Angew. Chem. Int. Ed. 2022, e202113519

Selected as a Hot Paper.

Paper 1

Accelerating reaction rates of biomolecules by using shear stress in artificial capillary systems
Hakala TA; Yates EV; Challa PK; Toprakcioglu Z; Nadendla K; Matak-Vinkovic D; Dobson CM; Martínez R; Corzana F*; Knowles TPJ*; Bernardes GJL*
J. Am. Chem. Soc. 2021, 143, 16401–16410

Highlighted in Chemistry World, “Tiny mechanical forces deform proteins in living systems for faster reactions”; in In The Pipeline, "Pushing Through the Capillaries"; and in Nature Chemical Biology, "Catalysis under stress".

Paper 2

Combating small-molecule aggregation with machine learning
Lee K; Yang A; Lin Y-C; Reker D; Bernardes GJL; Rodrigues T
Cell. Rep. Phys. Sci. 2021, 2, 100573

small molecular aggregation paper image

Arylethynyltrifluoroborate dienophiles for on demand activation of IEDDA reactions
Zawada Z; Guo Z; Oliveira BL; Navo CD; Li H; Cal PMSD; Corzana F; Jiménez-Osés G*; Bernardes GJL*
Bioconjugate Chem. 2021, 32, 1812−1822

IEDDA reactions paper image

METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation

Orellana EA; Liu Q; Yankova E; Pirouz M; De Braekeleer E; Zhang W; Lim J; Aspris D; Sendinc E; Garyfallos DA; Gu M; Ali R; Gutierrez A; Mikutis S; Bernardes GJL; Fischer ES; Bradley A; Vassiliou GS; Slack FJ; Tzelepis K; Gregory RI
Molecular Cell 2021, 81, 3323–3338

Previewed in Molecular Cell 2021, 81, 3243–3245 “m7G tRNA modification reveals new secrets in the translational regulation of cancer development

METTL1 paper image
Allosteric antagonist modulation of TRPV2 by Piperlongumine impairs glioblastoma progression

Conde J; Pumroy RA; Baker C; Rodrigues T; Guerreiro A; Sousa BB; Marques MC; Almeida BP; Lee S; Leites EP; Picard D; Samanta A; Vaz SH; Sieglitz F; Langini M; Remke M; Roque R; Weiss T; Weller M; Liu Y; Han S; Corzana F; Morais VA; Faria CC; Carvalho T; Filippakopoulos P; Snijder B; Barbosa-Morais NL; Moiseenkova-Bell VY; Bernardes GJL
ACS Cent. Sci. 2021, 7, 868–881

glioblastoma paper image
Facile installation of post-translational modifications on the Tau protein via chemical mutagenesis

Lindstedt PR; Taylor RJ; Bernardes GJL*; Vendruscolo M* (co-senior authors)
ACS Chem. Neurosci. 2021, 12, 557−561

Tau protein paper image

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody
Macías-León J; , Bermejo IA; Asín A; García-García A; Compañón I; Jiménez-Moreno E; Coelho H; Mangini V; Albuquerque IS; Marcelo F; Asensio JL; Bernardes GJL; Joshi HJ; Fiammengo R; Blixt O; Hurtado-Guerrero R; Corzana F
Chem Commun. 2020, 56, 15137–15140

Featured on the front cover

anti-MUC1 paper image

meCLICK-Seq, a substrate-hijacking and RNA degradation strategy for the study of RNA methylation
Mikutis S; Gu M; Sendinc E; Hazemi M; Kiely-Collins H; Aspris D; Vassiliou G; Shi Y; Tzelepis K; Bernardes GJL*
ACS Cent. Sci. 2020, 6, 2196−2208

Highlighted in First ReactionsGlobal Detection of RNA Methylation by Click Degradation
Highlighted in C&ENNew system cuts RNA using only small molecules
Featured in the J. Am. Chem. Soc. virtual issue "RNA chemistry"

Paper 4

Adaptive Optimization of Chemical Reactions with Minimal Experimental Information
Reker D; Hoyt EA; Bernardes GJL*; Rodrigues T*
Cell Rep. Phys. Sci. 2020, 1, 100247

Highlighted in Chemistry WorldMachine-learning software competes with human experts to optimise organic reactions
Listed in Cell Rep. Phys. Sci. in the “Best of 2020” collection

Paper 5

Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors
Seixas JD*; Sousa BB; Marques MC; Guerreiro A; Traquete R; Rodrigues T; Albuquerque IS; Sousa MFQ; Lemos AR; Sousa PMF; Bandeiras TM; Wu D; Doyle SK; Robinson CV; Koehler AN; Corzana F; Matias PM; Bernardes GJL*
RSC Chem. Biol. 2020, 1, 251–262

Highlighted in the 2021 Editors’ Choice collection

Serine-Selective Bioconjugation
Vantourout JC; Adusumalli SR; Knouse KW; Flood D; Ramirez A; Padial NM; Istrate A; Maziarz K; deGruyter JN; Merchant RR; Qiao JX; Schmidt MA; Deery MJ; Eastgate MD*; Dawson PE*; Bernardes GJL*; Baran PS*
J. Am. Chem. Soc. 2020, 142, 17236−17242

Highlighted in Synfacts 2021; 17(01): 0092, Serine-selective bioconjugation

Tetrazine carbon nanotubes for pre-targeted in vivo ‘click‐to‐release’ bioorthogonal tumour imaging
Li H; Conde J; Guerreiro A; Bernardes GJL*
Angew. Chem. Int. Ed. 2020, 59, 16023–16032

Selected as a Very Important Paper

Continuous flow reactors from microfluidic compartmentalization of enzymes within inorganic microparticles
Hakala T; Bialas F; Toprakcioglu Z; Bräuer B; Baumann KN; Levin A; Bernardes GJL*; Becker CFW*; Knowles TPJ*
ACS Appl. Mater. Interfaces 2020, 12, 32951–32960

Brain-sparing sympathofacilitators mitigate obesity without adverse cardiovascular effects
Mahú I; Barateiro A; Rial-Pensado E; Martinéz-Sánchez N; Vaz SH; Cal PMSD; Jenkins B; Rodrigues T; Cordeiro C; Costa MF; Mendes R; Seixas E; Pereira MMA; Kubasova N; Gres V; Morris I; Temporão C; Olivares M; Sanz Y; Koulman A; Corzana F; Sebastião AM; López M; Bernardes GJL*; Domingos AI*
Cell Metab. 2020, 31, 1120–1135

Previewed in Cell Metab. 2020, 31, 1043–1045 “A Sympathetic Treatment for Obesity
Highlighted in Nat. Rev. Endocrinol. 2020, 16, 343 “Unravelling novel weight loss mechanisms

A sweet galactose transfer: Metabolic oligosaccharide engineering as a tool to study glycans in plasmodium infection.
Kitowski A; Bernardes GJL*
ChemBioChem 2020, 21, 2696–2700

Evaluation of linker length effects on a BET bromodomain probe
Traquete R; Henderson E; Picaud S; Cal PMSD; Sieglitz F; Rodrigues T; Oliveira R; Filippakopoulos P; Bernardes GJL*
Chem. Commun. 2019, 55, 10128–10131

Development of a self-immolative linker for tetrazine-triggered release of alcohols in cells
Davies S; Oliveira BL; Bernardes GJL*
Org. Biomol. Chem. 2019, 17, 5727–5730

Azabicyclic vinyl sulfones for residue-specific dual protein labelling
Gil de Montes E; Jiménez-Moreno E; Oliveira BL; Navo CD; Cal PMSD; Jiménez-Osés G; Robina I; Moreno-Vargas AJ; Bernardes GJL*
Chem. Sci. 2019, 10, 4515–4522

Tetrazine-triggered release of carboxylic-acid-containing molecules for activation of an anti-inflammatory drug
Davies S; Qiao J; Oliveira BL; Navoc CD; Jiménez-Osésc G; Bernardes GJL*
ChemBioChem. 2019, 20, 1541–1546