SELECTED PAPERS
For citation analysis and h-index, check my Google Scholar.
Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination
Dunsmore L; Navo CD; Becher J; Gil de Montes E; Guerreiro A; Hoyt E; Brown L; Zelenay V; Mikutis S; Cooper J; Barbieri I; Lawrinowitz S; Siouve E; Martin E; Ruivo PR; Rodrigues T; da Cruz FP; Werz O; Vassiliou G; Ravn P; Jiménez-Osés G*; Bernardes GJL*
Nat. Chem. 2022, 14, 754–765
π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation
Taylor RJ; Rangel MA; Geeson MB; Sormanni P; Vendruscolo M; Bernardes GJL*
J. Am. Chem. Soc. 2022, 144, 14404–14419
Platform for orthogonal N-cysteine-specific protein modification enabled by cyclopropenone reagents
Istrate A; Geeson MB; Navo CD; Sousa BB; Marques MC; Taylor RJ; Journeaux T; Oehler SR; Mortensen MR; Deery MJ; Bond AD; Corzana F; Jiménez-Osés G*; Bernardes GJL*
J. Am. Chem. Soc. 2022, 144, 10396–10406
Accelerating reaction rates of biomolecules by using shear stress in artificial capillary systems
Hakala TA; Yates EV; Challa PK; Toprakcioglu Z; Nadendla K; Matak-Vinkovic D; Dobson CM; Martínez R; Corzana F*; Knowles TPJ*; Bernardes GJL*
J. Am. Chem. Soc. 2021, 143, 16401–16410
See highlights in Chemistry World, Tiny mechanical forces deform proteins in living systems for faster reactions, by Tim Wogan, in In the Pipeline, Pushing through the capillaries, by Derek Lowe, and in Nature Chemical Biology, "Catalysis under stress" by Andrew Bissette.
Conde J; Pumroy RA; Baker C; Rodrigues T; Guerreiro A; Sousa BB; Marques MC; Almeida BP; Lee S; Leites EP; Picard D; Samanta A; Vaz SH; Sieglitz F; Langini M; Remke M; Roque R; Weiss T; Weller M; Liu Y; Han S; Corzana F; Morais VA; Faria CC; Carvalho T; Filippakopoulos P; Snijder B; Barbosa-Morais NL; Moiseenkova-Bell VY; Bernardes GJL
ACS Cent. Sci. 2021, 7, 868–881
meCLICK-Seq, a substrate-hijacking and RNA degradation strategy for the study of RNA methylation
Mikutis S; Gu M; Sendinc E; Hazemi M; Kiely-Collins H; Aspris D; Vassiliou G; Shi Y; Tzelepis K; Bernardes GJL*
ACS Cent. Sci. 2020, 6, 2196−2208
Highlighted in First Reactions “Global Detection of RNA Methylation by Click Degradation”
Highlighted in C&EN “New system cuts RNA using only small molecules”
Featured in the J. Am. Chem. Soc. virtual issue "RNA chemistry"
Platinum-triggered bond-cleavage of pentynoyl amide and N-propargyl handles for drug-activation
Oliveira BL; Stenton BJ; Unnikrishnan VB; de Almeida CR; Conde J; Negrão M; Schneider FSS; Cordeiro C; Ferreira MG; Caramori GF; Domingos JB; Fior R; Bernardes GJL*
J. Am. Chem. Soc. 2020, 142, 10869–1088
Brain-sparing sympathofacilitators mitigate obesity without adverse cardiovascular effects
Mahú I; Barateiro A; Rial-Pensado E; Martinéz-Sánchez N; Vaz SH; Cal PMSD; Jenkins B; Rodrigues T; Cordeiro C; Costa MF; Mendes R; Seixas E; Pereira MMA; Kubasova N; Gres V; Morris I; Temporão C; Olivares M; Sanz Y; Koulman A; Corzana F; Sebastião AM; López M; Bernardes GJL*; Domingos AI*
Cell Metab. 2020, 31, 1120–1135
See preview in Cell Metab. 2020, 31, 1043–1045 “A Sympathetic Treatment for Obesity” by Jung Dae Kim and Sabrina Diano
Highlighted in Nat. Rev. Endocrinol. 2020, 16, 343 “Unravelling novel weight loss mechanisms” by Alan Morris
Enhancement of the anti-aggregation activity of a molecular chaperone using a rationally designed post-translational modification
Lindstedt PR; Aprile FA; Matos MJ; Perni M; Bertoldo JB; Bernardim B; Peter Q; Jiménez-Osés G; Knowles TPJ; Dobson CM; Corzana F; Vendruscolo M; Bernardes GJL*
ACS Cent. Sci. 2019, 5, 1417–1424
Chemo and regioselective lysine modification on native proteins
Matos MJ; Oliveira BL; Martínez-Sáez N; Guerreiro A; Cal PMSD; Bertoldo J; Maneiro M; Perkins E; Howard J; Deery MJ; Chalker JM; Corzana F; Jiménez-Osés G; Bernardes GJL*
J. Am. Chem. Soc. 2018, 140, 4004–4017
Highlighted in Chem. Eng. News, 2018, 96, 13 “Computer-designed reagent targets lysine for protein modification”; and in Phys.org “How to spark a chemical chain reaction”, 9 March 2018.
